The pressure value indicator of cerebrospinal fluid is very important to effectively assess the general intracranial status and is one of the cerebrospinal fluid physical examination items. Generally, the pressure measurement is most accurate at this time when a manometry tube is attached immediately after the lumbar puncture is done and the cerebrospinal fluid is visible. Under normal circumstances, the pressure of lumbar puncture cerebrospinal fluid ranges from 80 to 180 mm water column in adults in the lateral position and from 40 to 100 mm water column in children in the lateral position. To obtain a normal value of cerebrospinal fluid pressure, it must be measured accurately. First of all, the lateral recumbent position should be standard and should not be too high or too low. Secondly, if the cerebrospinal fluid pressure is very high and the cerebrospinal fluid gushes out because of certain disease changes, relevant treatment must be performed in time to prevent brain herniation. In addition, attention must be paid to the principle of asepsis, which, in the event of infection, can cause fever and headache. The last and most important point is to see the cerebrospinal fluid outflow and immediately connect to a manometry tube for measurement, which is the most accurate, and the pressure of the cerebrospinal fluid may change once a few drops are out. The pressure of the cerebrospinal fluid depends on the specific clinical lesion, and different cerebrospinal fluid pressures can assist in the diagnosis of different intracranial pathologies. For example, increased pressure is most often seen in intracranial lesions, such as various types of encephalitis, poliomyelitis, brain tumors, cerebral hemorrhage, and traumatic brain injury; decreased pressure is most often seen in spinal cord compression, spinal cord subarachnoid adhesions, subdural hematomas, etc.; nasal and ear leaks of cerebrospinal fluid after craniocerebral trauma, multiple releases of cerebrospinal fluid in a short period of time, and persistent ventricular drainage; and puncture needles that are not completely in the spinal canal.