Both empirical and statistical results have proven that poor gastrointestinal conditions do predispose to gallstones. The reasons are as follows: 1. When Helicobacter pylori infection in the stomach, the bacteria may enter the biliary system at the same time. Bacteria form chronic inflammation in the gallbladder, which makes the composition of gallbladder bile change and make it easy to form crystals, while the increase of mucus and other components in the bile makes the crystals further form solid stones. The chances of gallbladder cancer are also high in cases of stony cholecystitis caused by Helicobacter pylori; 2. Patients with intestinal diseases, such as Crohn’s disease and ulcerative colitis, are prone to gallstones. This is because the intestinal tract has a reduced ability to reabsorb bile acids, which is known as the impairment of the enterohepatic circulation, making the bile composition prone to change and produce gallstones. In addition, these patients often have to fast when serious, or intravenous nutrition, which will cause the gallbladder does not empty, bile can not be renewed and make the formation of bile mud, and further development of bouncing stones; 3, the early symptoms of gallstones may have similarities with gastrointestinal discomfort, so the beginning is mistaken for a bad gastrointestinal. Therefore, a bad gastrointestinal examination with an ultrasound will clarify whether there are gallstones, and then study why gallstones are formed. Based on this, see if there can be some preventive measures.