The prevalence of gallstones increases with age and is more prevalent in women. Female hormones, obesity, pregnancy, high-fat diet, long-term parenteral nutrition, diabetes mellitus, hyperlipidemia, post-gastrectomy or gastrointestinal anastomosis, terminal ileal disease and ileal resection, cirrhosis of the liver, and hemolytic anemia can increase the risk of gallstones. The main causes of gallstones may be: 1. Imbalance in the ratio of the main components of bile: the components of bile have been mentioned above, in addition to water, the solid components are bile salts, cholesterol, lecithin and other three main chemical components, mixed together in a viscous state as we all know, water and oil are incompatible. Cholesterol is a lipid substance, it is also insoluble in water; 2, biliary ascariasis: Ascaris lumbricoides is parasitic in the human small intestine, there are many kinds of bacteria in the small intestine, E. coli is the most common. Therefore, the bacteria adhering to the body of roundworm is also the most abundant with E. coli. And the roundworm has a special habit, is to see the hole to drill, no hole. There is a place in the duodenum called duodenal papilla, which is a very small hole, and this place is the necessary way for roundworms to enter the bile duct from the intestine; 3. Obesity and low physical activity: obese people have a higher cholesterol conversion rate than normal people, which increases the excretion of cholesterol in the bile and makes it easy to precipitate and form gallstones. The lack of exercise, sedentary habits, obesity, relaxation of the abdominal wall, prolapse of the liver in thin people, long-term lack of fat in the diet, and hypotonia of the gallbladder can cause chronic bile accumulation and gallstones; 5, mental state: long-term mental tension and depression can cause disorders of the visceral vegetative nerves, affecting the function of the gallbladder and causing bile accumulation. Because mental unhappiness can lead to a reduction in disease-resistant white blood cells, thereby undermining the function of the body’s immune system. Experts have observed a group of men who lost their wives, and their white blood cells decreased significantly in the first 14 months; 6. Genetics: It has been confirmed that the incidence of gallstones is higher in the next generation than in the general population. The incidence of gallstones is significantly higher in women than in men, and the main reasons for this are roughly the following: preferring to be quiet and less active, obesity, skipping breakfast, multiple pregnancies, and snacking after meals. Prevention of gallstones Dietary regulation is the most ideal prevention method to prevent the occurrence of gallstone disease and gallbladder cancer. In addition, cold, greasy, high-protein, stimulating food and strong wine are easy to help moisture and generate heat, which will cause bile accumulation, so you should eat less. If you have constipation symptoms, you should actively treat them. Vegetables and fruits rich in vitamin A and vitamin C, fish and seafood can help clear bile and dissolve stones, so you should eat more. It is also very important to have a regular life, pay attention to the combination of work and rest, participate in regular physical activities, eat breakfast on time, avoid gaining weight, and reduce the number of pregnancies. Drinking a glass of milk every night or eating a fried egg for breakfast can make the gallbladder contract and empty at regular intervals, reducing the time that bile stays in the gallbladder.