At present, general anesthesia is recommended for most gallstone surgeries. For some special reasons, semi-anesthesia can be considered, mainly including lumbar anesthesia or epidural anesthesia, depending on the differences of individual patients. If there are no special circumstances, general anesthesia is generally recommended for surgery.1. General: If gallstone surgery is performed through laparoscopic minimally invasive removal of the gallbladder, or laparoscopic bile duct exploration for stone extraction and T-tube drainage, general anesthesia must be performed. Because laparoscopic surgery must be performed with the establishment of an artificial pneumoperitoneum to instill gas into the abdominal cavity, the muscles have to be kept relaxed in this case, so the corresponding operation must be performed under general anesthesia. In the case of semi-anesthesia the patient is awake and will not be able to perform laparoscopic surgery. For traditional open surgery, general anesthesia or continuous epidural block anesthesia can be used for surgery; 2. Special cases: relative to some patients, if there are contraindications to general anesthesia, including poor respiratory function, pulmonary inflammation, severe insufficiency, abnormal coagulation, or in combination with the patient’s personal choice and other factors, semi-anesthesia can be used for surgery. If open cholecystectomy is performed, or bile duct exploration for stone extraction or T-tube drainage, continuous epidural anesthesia can be considered, but in general the anesthetic effect is poor, which can affect the prognosis and have an impact on the patient’s psychological health. Overall, the choice of general or semi-anesthesia for surgery should be based on the characteristics of the condition, anesthesia tolerance, and the general condition of the patient, with the choice of safe and simple anesthesia with fewer complications. It is recommended that before gallstone surgery, the patient must communicate fully with the anesthesiologist and choose the most suitable and safe anesthesia for his or her condition. Currently, the vast majority of gallstone surgeries are performed under general anesthesia, which in many cases is safer than semi-anesthesia surgery.