Secondary myelofibrosis may be associated with infections, tumors, chemical solvents, and other factors. Different causes are treated differently as follows: 1. Infection: such as tuberculosis. It is recommended to take oral anti-tuberculosis drugs (such as rifampicin, isoniazid, etc.) for treatment, and can also be treated by chemotherapy. 2. Tumor: it is a major cause of myelofibrosis, which is commonly seen in blood diseases (such as acute leukemia, etc.), metastatic bone cancer, etc. (1) Blood diseases: such as acute leukemia. It is recommended to take treatment under doctor’s guidance, such as oral retinoic acid, etc., chemotherapy or bone marrow transplantation. (2) Metastatic bone cancer: such as lung cancer, stomach cancer, breast cancer and other metastatic bone cancers. It is recommended to carry out standardized chemotherapy as early as possible under the guidance of doctors. (3) Chemical solvents: people who have long-term contact with organic solvents such as benzene and carbon tetrachloride. It is recommended to stop exposure to harmful substances immediately. If secondary myelofibrosis occurs, it is necessary to consult a doctor in time, improve systematic examination, identify the cause of the disease and treat it as soon as possible so as not to delay the condition.