The main difference between hepatitis B major triyang and hepatitis B minor triyang is that the positive items in hepatitis B 5 items are different, the viral replication ability and infectiousness are different. 1. Hepatitis B 5 positive items are different: hepatitis B triple positive refers to hepatitis B surface antigen, core antibody and e antigen positive in hepatitis B 5 items; while hepatitis B minor triple positive refers to surface antigen, core antibody and E antibody positive. 2. Different viral replication ability: Generally speaking, patients with hepatitis B major triple positive have strong replication of hepatitis B virus and are highly contagious; while patients with hepatitis B minor triple positive have weaker replication and are less contagious. There may be other differences between hepatitis B triple positive and triple positive, but both diseases are more damaging to the body, and it is recommended that patients consult the hepatology department of regular hospitals for further examination and treatment, and regular review.