Buttock groove itching and pain may be folliculitis, perianal eczema, contact dermatitis and other diseases, need to take iodophor, antibiotics (mupirocin, etc.), glucocorticosteroids (dexamethasone, etc.), calcium-modulated phosphatase inhibitors (tacrolimus, etc.), antihistamines (loratadine, etc.), anti-fungal drugs (fluconazole, etc.), etc., according to the cause of the disease and other drugs. 1. Folliculitis: patients need to follow the doctor’s advice to use povidone iodine solution, polyvinylidene iodide solution and other antibacterial lotions. Bacterial infections can be prescribed to use mupirocin, fusidic acid and other antibiotic ointment, while fungal infections need to be prescribed to use fluconazole lotion, econazole cream and other antifungal drugs. 2. Perianal eczema: patients need to use glucocorticoid drugs under the guidance of a doctor, such as dexamethasone, hydrocortisone, etc., as well as pimecrolimus ointment, tacrolimus ointment and other calcium-modulated phosphatase inhibitors, the more serious symptoms need to be prescribed oral loratadine, cetirizine and other antihistamines. 3. Contact dermatitis: patients need to follow the doctor’s instructions for external glucocorticosteroids, such as clobetasol propionate cream, mometasone furoate cream, etc., but also follow the doctor’s instructions for oral antihistamine drugs, such as chlorpheniramine maleate, phenylephrine and so on. It is recommended that patients with itchy buttock grooves go to the hospital, follow the doctor’s instructions to treat the primary disease with medication, do not self-medication.