The ratio of urine protein to creatinine should be less than 30mg/g, 200mg/g for micro-proteinuria, suggesting that it may be physiological conditions such as strenuous activities, eating a lot of high-protein food, etc.; can also be seen in pathological conditions such as glomerulonephritis, asymptomatic proteinuria. 1. Physiological conditions: such as strenuous activities, staying up late, eating a lot of high-protein food, etc., which can lead to an increase in the ratio of urinary protein to creatinine, there is no need for special treatment at this time, pay attention to rest, and a light diet can be. 2. Pathological conditions (1) Glomerulonephritis: clinical manifestations include edema, hypertension, hematuria, proteinuria, with or without transient renal function impairment. If necessary, renal puncture biopsy should be performed to clarify the specific type of pathology, to help assess the condition and guide treatment. (2) Asymptomatic proteinuria: refers to mild or moderate proteinuria without obvious symptoms such as edema and hypertension. It is common in mild glomerular lesions and tubulo-interstitial lesions. The prognosis is good, and most of them can be recovered after treatment. If there is an increase in the ratio of urine protein to creatinine, you should consult a regular hospital in a timely manner, complete the relevant examinations under the guidance of a physician to clarify the cause of the disease, and follow the doctor’s instructions for treatment.