Pressing pain in the epigastrium is often caused by the following reasons: first, cholecystitis combined with gallbladder stones, the patient’s right epigastrium will have obvious pressing pain. Sometimes there can be rebound pain and muscle tension, some patients can also touch the enlarged gallbladder, you need to go to the hospital to check the abdominal ultrasound, or abdominal CT and so on for clarification. Secondly, it may be caused by liver diseases, such as cirrhosis, malignant tumor of liver, liver abscess, or liver cyst. It is necessary to check the ultrasound of liver or CT of liver, MRI of liver, etc., and at the same time, it is necessary to check the blood routine, liver function, tumor markers, etc. for clarification. Thirdly, it may be caused by gastric diseases, such as gastric ulcer, gastric perforation, or malignant tumor of stomach. If the patient has pressure pain in the left upper abdomen, it may be caused by pancreatic or spleen diseases.