White spots on the legs may be caused by fungal infections, vitiligo and other diseases, which can be treated with ketoconazole and halometasone cream. 1. fungal infection: white spots on the legs may be caused by fungal infectious diseases such as lichen planus, you can use antifungal drugs, generally take topical drugs such as ketoconazole treatment, but also with oral drugs such as itraconazole and other treatments. 2. Vitiligo: is a pigment loss skin disease, manifested in the skin flaky white spots, can be used glucocorticoids, immunosuppressants, such as halometasone, betamethasone, tacrolimus ointment, etc., but also for autologous skin transplantation, narrow-spectrum ultraviolet irradiation treatment, and so on. It is recommended to go to the dermatology department for examination and treatment in a timely manner, and avoid blindly using medication on your own.