Long-term non-healing of wound 5 months after esophageal cancer surgery is often related to poor nutritional status, combined infection, diabetes, medication and other reasons. Patients need to go to the hospital for further follow-up in time to find out the specific reasons. 1. Poor nutritional status: the nutritional status of some patients is poor, due to the lack of nutrition, usually the wound is not easy to heal. Nutrition needs to be increased by intravenous or oral means to supplement protein and other nutrients, which can promote wound healing. 2. Wound infection: Infection can lead to non-healing wounds. The wound needs to be debrided, and if an abscess forms, it needs to be drained accordingly. After the infection is controlled, the wound can heal on its own. 3. Diabetes: diabetes triggered by hyperglycemia, for wound healing is very unfavorable, the need to use drugs to control the patient’s blood sugar, to promote wound healing. 4. Drugs: Some patients may be using cytotoxic drugs or hormonal drugs, which can delay wound healing. For wounds that do not heal for a long time, it is necessary to adjust the dosage of drugs in time and treat the symptoms. It is recommended that patients undergo regular post-operative review to identify the cause of non-healing wounds and target treatment.