Anti-double-stranded DNA antibodies are specific for SLE. A positive anti-double-stranded DNA antibody can confirm the diagnosis of SLE, and a positive anti-double-stranded DNA antibody is often indicative of SLE disease activity, and in lupus patients, attention is generally paid to monitoring the titer of anti-double-stranded DNA antibodies. If the titer of anti-double-stranded DNA antibody is elevated, it indicates the relapse of SLE and may lead to lupus nephritis, positive urine protein, etc. It needs to be monitored and treated, mainly with hormones, immunosuppressants, antimalarial drugs, etc. Hormones include methylprednisolone and prednisone acetate. Most of the hormones will be increased if the double-stranded DNA antibody titers are elevated, and will be reduced again when the disease is in remission. Immunosuppressants, including cyclophosphamide, morte-macrolimus, tacrolimus, cyclosporine, etc., are also added if urine protein is present.