Kidney cancer combined with liver metastasis cannot be cured, and surgical resection, interventional therapy, targeted therapy, immunotherapy and other options need to be chosen according to the situation. Kidney cancer is mainly primary renal cell carcinoma, and renal clear cell carcinoma is the main pathological type, and its treatment is related to the stage of the disease and the patient’s physical condition. Kidney cancer combined with liver metastasis is already in advanced stage of the disease, often losing the chance of surgical resection, and at this time, a comprehensive treatment program is needed. 1. Interventional therapy: commonly used interventional methods for liver cancer include vascular interventional therapy (including transcatheter hepatic artery perfusion chemotherapy, transcatheter hepatic artery chemoembolization, transportal vein interventional therapy, etc.) and non-vascular interventional therapy (including percutaneous ablation, ultrasound ablation, percutaneous radioactive particle implantation, etc.). Programs can be selected to treat liver metastases according to the situation. 2. Targeted therapy and immunotherapy: patients with advanced renal cancer often lose the chance of surgery, and can be treated with monotherapy or combined therapy of targeted drugs and immunotherapy. (1) Vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs) and mammalian target of rapamycin protein (mTOR) inhibitors can be used in the treatment of advanced renal cancer, such as sorafenib and sunitinib. (2) Recent studies have shown that immunotherapy, especially programmed death receptor 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors, such as navumab and tirilizumab, have brought new hope to patients. It is recommended to go to a regular hospital for a comprehensive assessment of the disease, follow the doctor’s instructions to cooperate with the treatment, choose the appropriate treatment program to improve the patient’s prognosis, in order to avoid delaying the disease. Please strictly follow the doctor’s instructions, do not self-medication.