Treatment of diabetic patients with combined hypertension

  It is well known that diabetes is a chronic disease that seriously endangers human health, and if a diabetic patient has hypertension at the same time, it increases the risk of cardiovascular disease. Compared to non-diabetic patients, the rate of hypertension is 1.5-2 times higher in diabetic patients. Diabetic hypertension is far more damaging to the heart, brain and kidneys than in patients with primary hypertension alone or diabetes alone. Therefore, the 1999 WHO International Society of Hypertension guidelines for the management of hypertension stipulate that all patients with diabetes mellitus who have hypertension are designated as high or very high risk and must be treated immediately with antihypertensive drugs to keep blood pressure under control at the desired level once detected.  Every patient with diabetes combined with hypertension, especially those with a history of diabetes for more than 5 years or high blood glucose levels and gestational diabetes, should be aware of the occurrence of cardiovascular disease, especially damage to the kidneys and fundus. Patients should have their fundus and urine microalbumin checked regularly. Patients with hypertension preceding diabetes should pay more attention to cardiac involvement and must have regular electrocardiograms and echocardiograms to clarify the diagnosis.  How should patients with diabetic hypertension choose antihypertensive drugs? It is currently accepted that patients with diabetic hypertension should first choose angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers. These drugs can not only lower blood pressure, but also protect renal function and reverse renal damage. However, because the blood pressure of diabetic hypertensive patients is often difficult to control to the ideal level with one antihypertensive drug, a combination of drugs should be considered.  Calcium antagonists have a protective effect on renal function in patients with diabetic hypertension, especially when combined with angiotensin-converting enzyme inhibitors to achieve ideal blood pressure control, while it has no adverse effects on the metabolism of blood glucose and blood lipids, so it is suitable for hypertensive patients with diabetes mellitus.  Selective β-blockers can also be used as combination antihypertensive drugs, but their masking of possible hypoglycemic symptoms should be avoided.  Diabetic hypertensive patients with diastolic blood pressure controlled at 80 mmHg are twice as good at preventing damage to the heart, brain and kidneys and cardiovascular disease than when controlled at 90 mmHg. Therefore, it is best to control the blood pressure of diabetic patients at a lower level. It is recommended that systolic blood pressure be controlled at 120 mmHg and diastolic blood pressure at or below 80 mmHg.