In real life, there are many diabetic patients combined with gallstones. According to relevant research data, diabetes is one of the important risk factors for gallstone disease, and about 31.5% of diabetic patients in China have gallstone disease in combination, which is significantly higher than non-diabetic patients. Why diabetes is easy to combine with gallstone disease Gallstone disease is the occurrence of stones in the gallbladder and bile duct, mainly cholesterol stones. One of the reasons for gallstones in diabetic patients is impaired lipid metabolism. Most diabetic patients, especially type II diabetic patients, have dyslipidemia, coupled with obesity and hyperinsulinemia, the body’s insulin cannot effectively inhibit lipolysis, and fat metabolism is disrupted, resulting in an increase in cholesterol synthesis in the liver, an imbalance in the ratio of cholesterol, bile acids and phospholipid content in bile, and poor water solubility of cholesterol in a saturated state, which makes it easy to form stones. Second, visceral autonomic dysfunction and microangiopathy. Visceral autonomic dysfunction and microvascular lesions affect the contraction function of the gallbladder, delayed emptying of the gallbladder, bile filling and stagnation, and poor outflow, which will lead to gallstone disease over time. In clinical practice, about half of the patients do not have any symptoms; some patients often feel stuffy and uncomfortable in the right upper abdomen, indigestion and other phenomena; some of them have large stones, once they block the jugular abdomen or the gallbladder duct, it can cause biliary colic or acute cholecystitis, with severe pain in the right upper abdomen, nausea, vomiting, fever and other symptoms; in serious cases, it can cause gallbladder necrosis and perforation, secondary biliary peritonitis, with toxic shock. If the common bile duct is obstructed by stones, the bile cannot be discharged smoothly to reach the small intestine, coupled with increased septic inflammatory exudation, resulting in increased biliary pressure, resulting in impaired hepatocyte function, secondary acute hepatic necrosis, endangering health and life, with a mortality rate of 26-30%. How to prevent and control gallstone disease in diabetic patients 1, control the blood sugar. Adhere to the reasonable application of hypoglycemic drugs, strengthen blood glucose monitoring, to ensure that fasting and postprandial blood glucose control within the ideal range. 2, low-fat diet. Daily meals should be strictly limited to high-fat foods, do not eat cholesterol-rich foods and stimulating foods, to help prevent dyslipidemia. 3.Supplement water. Drink more plain water, 2000~2500ml per day, which can dilute the blood and prevent the rise of blood viscosity. 4.Lipid regulating treatment should be actively carried out. Those with increased blood lipids should take reasonable lipid-regulating drugs to bring down excessive cholesterol, LDL cholesterol and triglycerides. 5, obese people should lose weight. Obese diabetic patients should adhere to moderate aerobic exercise to burn off excess calories and reduce body weight. 6, early detection and early treatment. Diabetic patients should have regular checkups, preferably an annual liver and gallbladder ultrasound, as well as early detection and treatment of gallstone disease. For gallstones, you can take choleretic drugs such as goose deoxycholic acid and ursodeoxycholic acid, or you can take herbal medicines that soothe the liver and benefit the gallbladder. In case of combined acute cholecystitis, antibiotics and antispasmodic and analgesic drugs should be used reasonably. For cholesterol stones up to 3 cm in diameter in the gallbladder, and for those with contractile gallbladder, extracorporeal shock wave lithotripsy can be used. If the patient has frequent episodes of acute cholecystitis, fever and severe abdominal pain, laparoscopic surgery can be done, but insulin must be given before and after the surgery, and the surgery must be done after the blood sugar is stabilized to ensure safety and facilitate recovery.