Coagulation factors are important proteins involved in the body’s coagulation function, coagulation factors involved in the process of coagulation, when bleeding, the body’s coagulation factors are activated, and platelets adhered together to form clots to play the role of hemostasis. 1. There are many kinds of coagulation factors, most of which are synthesized by the liver. The coagulation factors found to be involved in the coagulation function are coagulation factors I, II, III, IV, V, VII, VIII, IX, X, X, X, XL, Xlll, etc. The different coagulation factors are also involved in the coagulation process, and they can be activated when bleeding occurs. 2. Different coagulation factors are involved in different pathways of coagulation. (1) Exogenous coagulation pathway is involved by factor VII and factor X. When tissue injury occurs, tissue factor is released, which activates factor VII and forms a complex with the participation of calcium ions, which in turn activates factor X and exerts the coagulation function. (2) The endogenous coagulation pathway involves more coagulation factors, including coagulation factors Ⅱ, Ⅴ, Ⅷ, Ⅸ, Ⅺ, Ⅻ, etc. It firstly activates coagulation factor XII, then other coagulation factors, and ultimately activates fibrinogen, which forms a thrombus and stops bleeding. Coagulation factor is an important participant in coagulation function, and its abnormality requires standardized treatment under the guidance of a doctor.