If acute epididymitis is not treated timely and effectively, it is easy to cause infertility, weak spermatogenesis, testicular spermatogenic dysfunction and other diseases. 1. Infertility: repeated episodes of acute epididymitis lead to chronic epididymo-orchitis, and the inflammatory stimulus blocks the epididymal ducts, making it impossible for sperm to pass through, which may lead to infertility. 2. Weak Spermia: The inflammatory reaction of acute epididymitis makes the lumen congested and edematous, and the secretion of nutritive sperms by the epididymis decreases, resulting in a significantly higher ratio of inactive or dead sperms in the discharged semen, thus inducing Weak Spermia or Necrospermia. 3. Testicular spermatogenic dysfunction: acute epididymitis can cause secondary orchitis, and in the case of testicular involvement, it can also cause testicular spermatogenic dysfunction. Patients with acute epididymitis should follow the doctor’s instructions for effective treatment in time to avoid serious consequences.