Omeprazole enteric-coated capsules and Sishen tablets, there is no authoritative literature to show that the two drugs will interact with each other, it is recommended that the two be taken at an interval of more than half an hour. Omeprazole enteric-coated capsule, is a kind of acid-suppressing drug, can be used for the treatment of gastric ulcers, duodenal ulcers, reflux esophagitis and other diseases, can also be used for the eradication of Helicobacter pylori. It is prohibited for those who are allergic to omeprazole or other azole drugs; it is used with caution in pregnant and lactating women, children, the elderly, patients with impaired hepatic function and impaired renal function. Sishen Tablet, is a yellow-brown to brownish-brown tablet composed of nutmeg (simmered), the system of Cornu Cervi Pantotrichum, salt tonic bone resin, vinegar schizandra, dry ginger, jujube (core removed), etc., with a sour, pungent flavor. It has the efficacy of assisting kidney and dispersing cold, stopping diarrhea and eliminating flatulence. It can be used for kidney deficiency and cold, intestinal sounding and belly distension, diarrhea, food does not melt, prolonged diarrhea, yellow face and weak body. Adverse reactions, contraindications and drug interactions are not clear. Omeprazole enteric-coated capsules can and Sishen tablets, both should be taken under the guidance of a doctor, taking time more than half an hour apart, should not be unauthorized use of drugs.