A 28-year-old married woman with normal menstruation, 0-0-1-0, had one induced abortion two years ago at 13 weeks of pregnancy. The size of the intrauterine gestational sac was 4.66cm×1.82cm×2.40cm, and the yolk sac, embryo bud and primordial heart tube pulsation could be seen. The size of the embryo bud was 0.88×0.51cm, and there was no discomfort such as vaginal bleeding during the period. At the 12th week of pregnancy, the ultrasound found that the embryonic bud was 1.2cm long, but there was no fetal heart, so embryonic sterilizations were considered. The patient cried with the report card and asked: how could the pregnancy be fine and suddenly stop? Indeed, it is a great shock to anyone when a mother-to-be with high expectations is suddenly told that the fetus has long been dead. This also made me realize that it is time to talk about embryonic arrest. Embryo termination, medically known as an obstructed miscarriage, also known as a miscarriage at an advanced stage, is a special type of spontaneous abortion in which the embryo or fetus has died and remains in the uterine cavity without being able to be discharged naturally in a timely manner. This kind of miscarriage usually occurs in the early stage of pregnancy. Due to the influence of various aspects such as social and environmental factors, the incidence of retained abortion has been increasing in recent years, causing certain psychological and physiological trauma to the patients. What causes embryonic abortion? 1, chromosomal abnormalities: the most common cause, will lead to embryonic non-development, including the number of abnormalities and structural abnormalities, of which translocation and inversion in the abortion product of chromosomal structural abnormalities are the most common. 2, genital malformations: uterine malformations, occupational lesions of the uterus such as uterine adhesions, uterine adenomyoma can affect embryonic development. The endometrium is too thin or too thick to affect the implantation. 3, immune factors: pregnancy in the uterus of the embryo or fetus is actually a homologous transplant, is the combination of the parents’ genetic material, so and the mother can not be exactly the same. Anti-reproductive immune antibodies are closely related to this disease. 4, endocrine disorders: including human chorionic gonadotropin, prolactin, progesterone, estrogen, androgen, thyroxine, etc.. 5, systemic diseases and reproductive tract infections: pregnant women’s blood, circulation, urinary tract diseases may also affect the development of the embryo, infected pathogens are mainly the following: TORCH infection, Chlamydia trachomatis, Mycoplasma urealyticum, human microvirus B19, syphilis spirochetes and so on. 6, environmental factors: in early pregnancy, the embryo is extremely sensitive to the effects of drugs and environmental factors. Excessive exposure to radioactive substances and chemical substances and other harmful factors can lead to embryonic damage. In addition, excessive tension, anxiety, fear, sadness and other mental trauma, as well as some unclear reasons can lead to retained abortion. How to correctly determine the embryonic abortion 1, early pregnancy reaction disappears, there may be vaginal bleeding or abdominal pain, and some have no symptoms. 2, ultrasound examination can confirm the diagnosis, focusing on the size and shape of the fetal sac, embryonic buds and primitive heart tube pulsation. In normal pregnancy, the yolk sac can be seen in the 6th week of pregnancy, and in the 7th week of pregnancy, in addition to the yolk sac, the embryo buds and primitive heart tube pulsation can also be seen. If menstruation is irregular or the last menstrual period is not well remembered, the last menstrual period will be estimated from the first ultrasound examination. Embryo termination can be considered in the following cases: 1. The diameter of the gestational sac is >25mm, but still no yolk sac and/or embryo is seen; 2. The yolk sac and heart tube pulsation are still not seen on the ultrasound after 2 weeks for the gestational sacs without yolk sac, and 10 days for the gestational sacs with yolk sac, which is characterized as a wilted sac or an empty sac; 3. The embryo is >7mm long, but still no fetal heart pulsation is seen. How to deal with embryonic failure? 1.Take blood for routine blood test and coagulation four items. 2.Pharmacological abortion + hysterectomy. As the embryo has died and stayed in the uterine cavity for a long time, the pregnancy tissue is mechanized and adheres to the uterine wall, which will increase the difficulty and risk of surgery, and even cause coagulation dysfunction. Therefore, at present, most of the clinics give medication before surgical treatment. (1) Commonly used drugs include mifepristone and misoprostol: mifepristone and misoprostol can play the dual role of inducing contractions and softening the cervix, which can accelerate the natural discharge of embryonic tissue from the uterine cavity. Mifepristone 150mg fasting oral 36 ~ 48h, and then take the first 3 tablets of misoprostol, complete abortion rate of 37.7 ~ 52%, incomplete abortion rate of 58.9 ~ 82%. (2) Surgical treatment: including purging, negative pressure suction, hysteroscopy, etc. as supplementary treatment after incomplete abortion. What items should be checked before pregnancy? (1) Genetic factors: chromosome and embryo karyotype analysis of both husband and wife. 2.Anatomical and structural factors of the reproductive tract: vaginal ultrasonography, hysterosalpingography, hysteroscopy. 3.Immunization factors: antiphospholipid antibody spectrum, antisperm antibody, antinuclear antibody (ANA), closed antibody (APLA) and so on. 4. Reproductive endocrine factors: sex hormone 6, anti-mullerian hormone, thyroid function measurement. 5. Reproductive tract infection factors: TORCH test, Chlamydia trachomatis, Mycoplasma urealyticum. 6, coagulation function measurement: D-dimer (DD), protein S (PS), homocysteine (HCY). 7.Male factor: semen examination. 8.Question the medical history, exclude diabetes, hypertension and genetic history, weighing. Check blood routine, urine routine, biochemistry, blood type, hepatitis B, hepatitis C, HIV and RPR. If there has been an embryo abortion, it is recommended to do a good preconception examination before the next pregnancy, and deal with any problems in time, so as to prevent the reappearance of induced abortion, which may cause another damage to the body.