Enlarged pores on both sides of the nose may be caused by physiological factors, such as heredity, or by diseases such as acne vulgaris and seborrheic dermatitis. You can take medication and physical therapy to improve the condition. 1. Physiological factors: Enlarged pores on both sides of the nose may be caused by heredity. Generally there is no need to take special treatment, if you think it affects the aesthetic appearance, you can improve through physical therapy, such as photorejuvenation, fractional laser, etc., which can make the skin delicate and reduce the size of pores. 2. Acne vulgaris: Large pores on both sides of the nose can also be caused by acne vulgaris, you can follow the doctor’s instructions to apply retinoic acid cream, tazarotene gel and other retinoic acid drugs, which can reduce the secretion of sebum and promote the receding of rashes, thus improving the symptoms. 3. Seborrheic dermatitis: Seborrheic dermatitis may also lead to large pores on both sides of the nose, can be used under medical supervision, keratolytic drugs, such as urea ointment, salicylic acid ointment, etc., with the topical application of ketoconazole cream, which is beneficial to improve the symptoms of large pores. There are many reasons for the enlarged pores on both sides of the nose, after excluding physiological factors, it is recommended that the patient go to the hospital, to clarify the cause of the disease, and standardized treatment under the guidance of the doctor.