Fever after HFMD vaccination is considered to be an adverse reaction to the vaccine. Since most of the vaccines are live attenuated vaccines, some children may develop fever and rash after vaccination, which can be treated with fever reduction according to the degree of the child’s fever. Treatment 1. Body temperature below 38.5℃: You can use physical cooling, warm water to rub the body, such as the neck, armpits and thigh roots, which is good for heat dissipation, or put on antipyretic stickers, drink more water, urinate and sweat can help the body temperature drop faster, and give the child some light and easily digestible food. Pay attention to keeping warm during fever reduction to avoid excessive loss of body fluids leading to hypothermia; 2. Body temperature above 38.5℃: Consider applying antipyretic drugs, and take oral antipyretic drugs such as acetaminophen as prescribed by the doctor. Allow at least 4 hours between two doses of antipyretics, and urge the child to drink more water in between, while carrying out physical cooling. In general, fever caused by vaccine reaction will be relieved soon. If the baby’s fever persists or other accompanying symptoms appear, it may be caused by other infections and the baby needs to be taken to the hospital for further clear diagnosis.