Low platelets due to cirrhosis with splenomegaly need to be treated with medications to elevate platelets, including oral medications and injections, and splenectomy is also feasible. The mechanism of thrombocytopenia due to splenomegaly in liver cirrhosis is caused by hypersplenism due to enlarged spleen, which leads to increased platelet destruction. For treatment, drugs such as oral Ricodrine tablets and aminopeptide tablets can be taken to elevate platelets; drugs such as recombinant human thrombopoietin and interleukin-11 can also be injected subcutaneously. If some patients still have very low platelet counts after drug treatment, and are at high risk of intracranial hemorrhage, gastrointestinal hemorrhage, or are accompanied by severe hemorrhagic manifestations such as skin and mucous membrane hemorrhage, splenectomy may be performed. It is recommended that the patient should consult a specialist in time, and the specialist should formulate an individualized treatment plan according to the patient’s specific condition.