Non-concave mucinous edema is the characteristic clinical response to thyroid hormone deficiency in adults. Primary hypothyroidism (hypothyroidism) is the most common type and is probably an autoimmune disease. It usually occurs as a result of Hashimoto’s thyroiditis and is often accompanied by a firm enlarged thyroid gland, which later develops as the disease progresses to a shrunken, fibrous thyroid with no or little function. The second most common type is post-treatment hypothyroidism, especially due to hyperthyroidism with radioactive iodine and surgical treatment, propylthiouracil, tabazol and iodine overtreatment of hypothyroidism, which often recovers after termination of treatment, and mild hypothyroidism commonly seen in older women. So how is non-concave mucinous edema examined? Here’s what you need to know. If the skin is pressed locally (such as the inner ankle, anterior tibial area, or frontal or zygomatic area) with a finger and does not appear depressed, it is called non-depressed edema. Primary hypothyroidism signs and symptoms form a remarkable pair with hyperthyroidism and the onset can be insidious and elusive. Facial expressions are sluggish, hoarse and slow in speech; mucopolysaccharide infiltration due to vitrous acid and chondroitin sulfate causes significant facial and periorbital swelling and fear of cold. Droopy eyelids due to lack of adrenergic impulses, sparse, coarse and dry hair, dry, rough, scaly flaking and thickened skin. Moderate weight gain, mainly due to reduced food metabolism and water retention. Patients are amnesic and show intellectual impairment with progressive personality changes. Some manifestations are melancholic and there may be significant psychosis (mucinous edema mania).