Pruritus is severe at night, may be related to mental factors, physiological rhythm regulation disorders, cytokines and prostaglandin secretion and other factors.
1. Psychological factors: at night, especially before going to bed often reduce external stimuli and often feel bored, people will be more obvious to the feeling of itching, mental tension will also aggravate the feeling of itching.
2. Physiological rhythm regulation disorders: hypothalamus a pituitary axis is an important endocrine axis regulating the body’s physiological rhythm, which adrenocorticotropic hormone levels usually fall to the lowest value at night, its anti-inflammatory effect is also reduced to a minimum, making it become one of the reasons for the itchy skin symptoms at night variants.
3. Secretion of cytokines and prostaglandins: It has been shown that the secretion of interleukin-2 and prostaglandins increases at night, causing increased itching.
In addition to this, the increase in transdermal water loss at night, the rise in body surface temperature at night and other factors can also lead to itchy skin to get symptoms aggravated compared to the daytime.
When symptoms of itching appear, you should go to the hospital in time, to clarify the cause of the disease and follow the doctor’s instructions for treatment.