There are many causes of severe vomiting such as food poisoning, gastroenteritis, pregnancy, etc. Symptoms can be improved by metoclopramide antiemetic, antibiotics, comfort and encouragement. Violent vomiting is usually due to stomach cramps, which belongs to the self-protection of the body. Firstly, the cause should be clarified and actively treated. 1. If severe vomiting is caused by food poisoning, if the patient can tolerate it, he or she can continue to vomit and expel as much poison as possible, and then drink water or saline to prevent the body from losing too much water. If the patient cannot tolerate it, metoclopramide can be used to relieve vomiting and fluids can be given to minimize fluid loss. 2. If acute gastroenteritis causes severe vomiting, metoclopramide can be used to stop vomiting, and antibiotics such as levofloxacin can be used for anti-infection treatment. 3. If severe vomiting occurs in early pregnancy, it is a normal phenomenon, which can be alleviated through comfort, encouragement, distraction and other ways to alleviate the symptoms, and should not be used casually in order to avoid affecting the development of the fetus. The above drugs are prohibited for those who are allergic to them and should be taken in accordance with medical advice. If the patient suffers from severe vomiting, it is recommended to go to a regular hospital in a timely manner, after clarifying the cause of the disease, under the guidance of the doctor to carry out targeted treatment.