The creatinine is a little bit higher in four times of reexamination, this phenomenon can be found in people who are particularly robust and have large muscle mass (such as athletes), and it can also be found in physiological conditions such as excessive intake of meat, strenuous activities, or some pathological reasons such as renal insufficiency, and then we should find out the reasons and treat the causes of the disease. The normal value of blood creatinine is 53-106μmol/L for men and 44-97μmol/L for women, and the elevation of creatinine and whether there is any problem of kidney should be combined with the urine routine, renal imaging, and other renal function indexes such as cystatin C and endogenous creatinine clearance. 1. Physiological reasons: excessive intake of meat food, drinking less water for a long time, strenuous activities can accelerate the body’s catabolism to produce creatinine and thus high values, usually two weeks to one month after changing bad habits can be restored. 2. Pathological causes: patients need to follow long-term medical treatment, which can be seen in fever, acute gastroenteritis, renal insufficiency, diabetes mellitus, severe infections, hypertension, kidney injury, systemic lupus erythematosus, anemia, and drug damage, etc., which need to be actively treated. In addition It is recommended that patients should go to the nephrology department of regular hospitals for consultation and treatment, and complete the relevant examinations to clarify the diagnosis and treatment.