Wake up at 2 o’clock in the middle of the night, most of them are caused by the existence of mental and psychological factors of the patient, for example, the patient because of nervousness or stress, and there are some things bothering the patient, after waking up at 2 o’clock in the middle of the night, they may think about these things and make it difficult to fall asleep. It is recommended that patients take this natural treatment, do not just take drugs to interfere with the sleep process, patients can adjust their mind. Also during the daytime to participate in more physical activities, so that the body is stronger, so that the body is in a state of fatigue, the depth of sleep at night there is an improvement in the depth of sleep, may be in the middle of the night at 2 o’clock will not wake up. There is also after adjusting themselves, is still in the middle of the night 2 o’clock wake up can not sleep, in this case it is recommended that the patient can take oral dexzopiclone, diazepam, eszopiclone this class of drugs to improve sleep.