Cranial repair is a relatively routine procedure in neurosurgery and the technique is very mature. Currently, it is very important to choose the right repair material for cranial repair. A good repair material can achieve more ideal repair results and reduce the incidence of postoperative discomfort; however, if the repair material is not properly selected, various problems may arise. A more widely used clinical material for cranial repair is titanium mesh. It is a relatively traditional cranial repair material and has been used for 20 to 30 years. Compared with the earlier materials, titanium mesh is advanced. However, this metal mesh material also has some defects and shortcomings, such as postoperative infection, rejection, wear and tear of the scalp, resulting in material exposure; titanium mesh insulation is not good, the patient is sensitive to the external hot and cold environment discomfort; titanium mesh metal material, will affect the patient to receive postoperative CT, magnetic resonance examination; can not do fine complex shaping. Another important point is that the titanium mesh is not too hard, not strong enough, if again subjected to external force, it is easy to cause the titanium mesh collapse deformation, and may even injure the brain tissue, very dangerous. PEEK material is a new type of special polymer material, called polyether ether ketone, which is very hard, low density, high strength, and good protection performance. The PEEK material has excellent properties in terms of histocompatibility, elasticity, heat conduction, hardness, stability, and radiolucency, and is comparable to autologous cranial bone, effectively avoiding the problems that can arise with titanium mesh and becoming a new trend in cranial repair materials. Our team not only uses this new material extensively, but also continuously carries out technical improvement and upgrade and material optimization design, and introduces the concept of aesthetic plastic surgery, so as to carry out comprehensive PEEK cranial bone repair and plastic surgery, achieving the organic unity of anatomical integrity, functional perfection and aesthetic appearance, which is widely praised.