The blisters on the hands can be handled differently according to the size of the blisters, for example, smaller and asymptomatic blisters are mainly observed; large blisters can be drained by puncture with a sterile needle, and blisters accompanied by signs of infection need to be treated with antibiotics. 1. For small and painless blisters, there is generally no need for much treatment, mainly for observation, and the blisters can subside on their own. 2. For larger blisters, a professional doctor can use a sterile needle to puncture and drain the fluid in the lower part of the blister, and pay attention to good disinfection before and after pumping the fluid to avoid infection. 3. For blisters with signs of infection, anti-infective treatment, such as topical complex iodine solution, erythromycin ointment, etc., should be carried out under the guidance of the doctor. Due to the variety of clinical manifestations, it is recommended to consult a doctor in a timely manner, and the specific situation requires a doctor’s consultation before deciding on the treatment.