Laser treatment is one of the cosmetic dermatology techniques that can be used clinically to treat pigmented skin diseases such as café-au-lait spots. Laser treatment is a technology that utilizes the electromagnetic radiation energy of laser to produce a limited effect on target tissues and play a therapeutic role. It has selective photothermal effect, which can cause selective damage to the target target and little damage to normal tissues. Neurofibromatosis cafe au lait is a reactive proliferation of fibroblasts caused by small skin injuries, and its lesions can be treated with laser. Lasers are also used clinically to treat vascular skin diseases such as hemangiomas. It is non-invasive or minimally invasive, short recovery period, safe and effective. It is recommended that patients suffering from neurofibromatosis should seek medical treatment in time and standardize the treatment under the guidance of doctors.