Clinically, it is not recommended to take pravastatin sodium tablets and atorvastatin calcium tablets at the same time, because these two drugs are lipid-lowering drugs, and belong to the same class of lipid-lowering drugs, that is, statins, and taking them at the same time may increase the risk of drug use. Pravastatin Sodium Tablets and Atorvastatin Calcium Tablets both belong to the statin class of lipid-lowering drugs, and the mechanism of action is to inhibit the activity of hydroxymethylglutarate monoacyl-coenzyme A reductase, which in turn lowers cholesterol. When the two drugs are used together, not only can they not play a more powerful lipid-lowering effect, but also increase the chance of adverse reactions. Both Pravastatin Sodium Tablets and Atorvastatin Calcium Tablets may have adverse effects on hepatic function, which may result in elevated aminotransferases; neurologic effects, which result in dizziness and headache; gastrointestinal effects, which result in nausea, vomiting, acid reflux, and abdominal pain; and, most importantly and most seriously, muscular effects, which result in myalgia and rhabdomyolysis. It should be noted that the drug is contraindicated in people who are allergic to the components of the drug, patients with active liver disease, pregnant or lactating women. Use with caution in patients with trauma, major surgery, severe infections, low blood pressure, uncontrolled epilepsy, as well as excessive alcohol consumption and a history of liver disease. When lipid-lowering therapy is needed, the medication should be administered under the guidance of a specialist according to the characteristics of hyperlipidemia, and unwarranted combination of drugs should be avoided in order to prevent serious adverse effects.