Obstetric management of pregnancy with hepatitis B is divided into early pregnancy, middle and late pregnancy, labor and delivery and puerperium, and mother-to-child interruption of hepatitis B is needed if the HBV DNA load is high. 1. Early pregnancy: In early pregnancy, if hepatitis B is mild, it should be actively treated and the pregnancy can be continued. Chronic active hepatitis B is more threatening to mother and child after pregnancy, and the pregnancy should be terminated after appropriate treatment. 2. Middle and late pregnancy: if HBV-DNA load is ≥2×10⁶IU/ml in middle and late pregnancy, tenofovir or telbivudine can be given as antiviral therapy under the guidance of doctors from 24 to 28 weeks of pregnancy to reduce mother-to-child transmission of HBV. 3. Delivery period: Vitamin K1 can be injected intramuscularly 3 days before delivery. 4. Puerperium: pay attention to rest, nutrition and hepatoprotective treatment during puerperium. Hepatitis B women should get pregnant at least half a year after hepatitis B is cured, preferably two years later. If you are pregnant with hepatitis B, you should go to the hospital in time for diagnosis and treatment under the doctor’s guidance.