HPV (human papillomavirus) 16 does not turn negative for a few years can be cancerous is uncertain, generally persistent infection for more than 2 years is likely to be cancerous. HPV16.18 virus is the main cause of cervical cancer, so, once diagnosed with HPV16 infection, you need to do further TCT (cervical fluid-based cell) examination, or colposcopy, cervical biopsy of suspicious tissues, if there is no problem, it is recommended that in three months to six months or so, to achieve early detection of pre-cancerous lesions early treatment. After HPV infection, if the body’s immunity is relatively good, it can usually turn negative in about 1 year. If the infection persists for more than 2 years, it may become cancerous. If the infection persists for more than 1 year, it is necessary to improve the resistance, apply interferon gel to assist in the treatment if necessary, follow up closely, and if there is any abnormality, give physical therapy or surgical treatment in a timely manner. HPV16 infection is not scary, close follow-up, early detection, early diagnosis, early treatment, can avoid cervical cancer.