When bitten by a large spider, the skin may induce allergic symptoms, with redness, swelling, itching, and pain on the skin. In severe cases, symptoms such as cardiac arrhythmia, respiratory distress and delirium may occur. Usually big spiders have a neurotoxin component in their bodies, and when bitten by a big spider, the toxin can pass through the bite site and rapidly enter the body’s bloodstream, destroying cells and tissues in the bloodstream. The patient will experience skin allergy symptoms, such as redness, swelling, itching, burning and oozing of the skin. If the toxicity spreads quickly, it can also cause systemic symptoms, and patients can experience arrhythmia, hypoxia, respiratory distress, delirium, muscle weakness and fatigue, fever, etc., which can seriously jeopardize the health of patients. Therefore, once a patient is bitten by a big spider, he or she should firstly squeeze the residual venom from proximal to distal end, rinse the local skin with running water, consult a doctor in time, and actively cooperate with the doctor to take relevant treatment measures.