Multiple slightly enlarged lymph nodes in the mediastinum are treated medically or surgically depending on the etiology such as respiratory infection, mediastinal tumor. 1. If the lymph nodes are enlarged due to bronchial infection or lung infection, medication should be used. For bacterial infection, oral or intravenous antibiotics such as cephalosporin and penicillin can be given to relieve the symptoms. For viral infections, antiviral drugs such as ribavirin can be taken. Usually, the enlarged lymph nodes can subside slowly and the prognosis is good. 2. If the disease is caused by malignant tumors, such as thymus tumor, breast tumor or lung tumor, pathological biopsy is usually performed first, and after diagnosis, surgical resection and lymph node dissection of the surrounding tissues are carried out, supplemented with radiotherapy, which has a poorer prognosis, and should be followed up regularly in order to avoid recurrence and deterioration of the disease. It should be noted that if the disease deteriorates or worsens without remission, it is necessary to go to the hospital in a timely manner for treatment under the guidance of a doctor.