Sertraline is an antidepressant, and the half-life of the drug is related to the metabolism completion in the body after discontinuation. For most drugs, after more than 5 half-lives, the drug is basically metabolized from the body. Sertraline is a drug with a relatively long half-life, with a half-life of 62-104 hours. According to the calculation, after 5 half-lives, if patients take sertraline continuously, sertraline will take at least 10-20 days to be metabolized from the body, so sertraline is a drug with a long metabolism time. Patients taking drugs that interact with sertraline should take them at longer intervals to avoid drug interactions. Sertraline is used for the treatment of depression. Common adverse reactions in patients include dry mouth, excessive sweating, dizziness, tremor, diarrhea, and dyspepsia. Patients are advised to undergo standardized evaluation and standardized use under the guidance of a physician.