Nifedipine extended-release tablets and amlodipine are not recommended for joint use, both have similar mechanisms of action, there is no need to combine, and joint use may increase the adverse effects of the drug. Nifedipine extended-release tablets and amlodipine are calcium antagonists, the main effect is to dilate coronary arteries and peripheral blood vessels, clinically used in the treatment of hypertension and coronary heart disease patients. For patients with poorly controlled blood pressure levels, joint treatment with antihypertensive drugs is required, but the joint use of nifedipine extended-release tablets and amlodipine is not recommended, as their combined use may result in a significant increase in adverse drug reactions. The adverse reactions of nifedipine extended-release tablets and amlodipine include lower limb edema, reactive tachycardia, flushing, dry stools, etc. They are contraindicated in patients with allergy to drug components, severe aortic valve insufficiency, and hypotension. Clinically for severe hypertension need to combine drugs, under the guidance of the physician to choose the combination of drug programs.