Rabies vaccine can usually be given while taking medication, although patients with convulsions, epilepsy, and chronic illnesses should be injected with caution and closely monitored after vaccination to be alert for adverse reactions. If the vaccination after exposure, there is no contraindication, no matter whether it is taking medicine or then other treatment, generally should be vaccinated with rabies vaccine, because rabies is a lethal disease. However, patients with convulsions, epilepsy, chronic disease patients are taking medication during the injection of rabies vaccine needs to be strictly monitored, there is discomfort should be timely consultation. If you are taking some immunosuppressants such as methotrexate or anti-malarial drugs such as chloroquine, it may lead to failure of immunization, but still need to be vaccinated in a timely manner, and closely monitor the efficacy. Rabies vaccine can be given during the period of taking medication. If there is any discomfort after vaccination, you should go to the hospital in time, and treat the symptoms under the doctor’s guidance.