Monkeypox is contagious. Monkeypox is a zoonotic infectious disease caused by the monkeypox virus, which is contagious and spreads mainly through the respiratory tract, digestive tract and contact. Patients may experience symptoms such as rash, fever, malaise, muscle pain, etc. Monkeypox is self-limiting, but severe cases may be co-infected, respiratory distress syndrome, or even lead to death. Once diagnosed with monkeypox, it needs to be isolated and treated in a specialized infectious disease hospital. In daily life, the disease can be prevented by avoiding monkeypox virus infection. For example, enhance the awareness of personal protection and avoid contact with sick animals or monkeypox patients. For monkeypox patients or contacts of infected animals, smallpox vaccination can be used to prevent the occurrence of monkeypox in humans. At the same time, it is also necessary to live a regular life, avoid staying up late, and strengthen physical exercise appropriately to enhance physical fitness, and so on. Once fever, malaise, and unexplained rash occur after contact with an animal, one should consult a doctor for diagnosis and appropriate treatment if necessary.