When patients wake up in the morning with puffy eyes and face, it may be caused by physiological reasons, and it may also be related to kidney disease and heart disease. 1. Physiological reasons: If patients drink a lot of water before going to bed the night before, cry for a long time, stay up late for a long time, lack of sleep, etc., it may cause patients to wake up in the morning with swollen eyes and face, which is a physiological phenomenon and generally does not need special treatment. 2. Kidney disease: when patients suffer from acute glomerulonephritis, renal insufficiency and other diseases, because the kidney metabolism of water ability to decline, the patient may appear in the eyes and face edema performance, the patient may also appear in the lower limbs edema, hematuria and other uncomfortable symptoms. 3. Heart disease: Patients suffering from heart disease, because of heart insufficiency, there may be blood circulation disorders, water retention in the tissues, so that the water can not be discharged out of the body normally, the patient may be manifested as edema of the lower limbs, and in severe cases, there may be the performance of the swelling of the eyes and face when waking up in the morning. It is recommended that patients with obvious swelling of the eyes and face should consult a doctor in time to assess their condition and follow the doctor’s instructions.