Blood vessels are the richest tissues in our body, they are distributed in all parts of the body, and their structure and function are directly related to the function of the related organs. The blood vessels of the human body usually suffer from the internal impact of the blood flow and the influence of various components (lipids, blood sugar, uric acid stimulation), and from time to time they also have to be destroyed by external intravenous fluid components. An increasing number of studies have found that many diseases start in the endothelial cells of the blood vessels, which when stimulated can secrete a variety of cytokines that induce an inflammatory response and initiate the progression of chronic diseases such as atherosclerosis, hypertension, thrombotic diseases, and vasculitis syndromes. In addition, external factors (e.g., hypertension, local compression, psychological factors, etc.) can increase the tension of the entire blood vessel, which, over time, can cause vascular thickening and a series of pathophysiological damages to the blood supply organs. Nowadays, some diseases with genetic defects, such as polycystic kidney (nearly half of them are combined with hemangioma) and hereditary vascular developmental defects, are more and more common in clinical practice, which are not only related to the improvement of our diagnostic technology, but also to the acceleration of their lesions by environmental and dietary factors and bad habits. However, the impact of vascular disease on human health is generally not given enough attention in clinical practice, as reflected in the little attention paid to screening for vascular disease. Vascular disease screening should do those examinations Vascular examination can be divided into general screening and targeted examination, the former is mainly to roughly understand the basic condition of vascular function, while the latter is mainly for some high-risk groups. Common screening items include: 1, mainly including heart rate, blood pressure, fasting blood sugar, blood lipids, liver function, kidney function, uric acid and other physiological and biochemical examination items; 2, blood rheological twin: plasma viscosity, blood sedimentation, pressure volume, whole blood high cut relative index, whole blood low cut relative index, blood sedimentation equation K value, red blood cell aggregation index, whole blood low cut reduction viscosity, whole blood high cut reduction viscosity, red blood cell rigidity index, red blood cell Deformation index, through the detection of dynamic changes in blood flow, can indicate the viscosity of blood, especially important for the elderly and vascular disease population, is an auxiliary examination for patients with hypertension, diabetes, cardiovascular disease. 3.Gene test: At present, there are mainly gene tests for hypertension, diabetes, hyperlipidemia, and gene tests for antiplatelet drug metabolism. CADASIL gene/HERNS gene/FABRY/MELAS gene test/apoE gene, which is related to hereditary cerebrovascular disease. 4.Twelve-lead resting electrocardiogram, abdominal ultrasound and chest x-ray, etc. 5.Carotid ultrasonography: mainly detects carotid intima-media thickness (IMT), plaque and determine the degree of stenosis, etc. 6.Pulse wave velocity (PWV) and ankle brachial index (ABI) examination: PWV and ABI examination are commonly used to detect the function of arterial elasticity and the risk of atherosclerosis. 7.Cardiac ultrasonography: It mainly observes structural changes of the heart and can be used to predict cardiovascular events (including stroke) and all-cause death. 8, Ambulatory blood pressure monitoring: It can dynamically monitor and analyze 24-hour systolic and diastolic blood pressure and diurnal blood pressure fluctuation changes between individuals, not only to comprehensively observe blood pressure fluctuation, but more importantly, to assess the elastic function of large arteries by diurnal blood pressure model and blood pressure variability analysis, to detect cardiovascular target organ damage early, and to predict the risk of cardiovascular events, especially strokes. The following items are available for biased cerebrovascular disease screening: 1. Color dual-function Doppler neck vascular ultrasound (Duplex): has an important suggestive value for the assessment and screening of large artery stenosis and occlusion in the neck and intracranial region. 2.Transcranial Doppler (TCD): mainly applied to the diagnosis of stenosis and occlusion of cerebral blood supply arteries and its effect on cerebral hemodynamics and detection of microemboli. 3.Digital subtraction angiography (DSA): It is the most accurate test for the diagnosis of cerebral vascular stenosis or occlusion, which can show not only large vessel lesions, but also small vessels (0.5mm in diameter), venous system and the condition of collateral circulation, and can provide detailed information for surgery or interventional treatment of aneurysm or arteriovenous malformation, and its sensitivity and specificity can reach 98%. 4.CT angiography (CTA): After intravenous injection of contrast agent, thin layer volume scan is performed using spiral CT, and then computerized three-dimensional reconstruction of blood vessels, so as to reflect the overall situation of blood vessels and calcification. It is mainly used for the examination of intracranial aneurysm, arteriovenous malformation, vascular stenosis, etc. 5.Magnetic resonance angiography (MRA): It is a non-invasive magnetic resonance angiography technique that uses the difference between the MR signal of flowing blood and the MR signal of surrounding stationary tissues in nuclear magnetic resonance (MRI) technology to establish image contrast without introducing any contrast agent. It is suitable for patients who are old and frail, have poor general condition and cannot perform DSA. It can obtain clear three-dimensional angiography in a short period of time and shows satisfactorily the stenosis or occlusion of large vessels and their branches, but not well for arteries below 20 mm. Since MRA imaging is related to blood flow, blood flow at bifurcations, eddy currents, etc. can lead to signal loss and thus exaggerate the degree of stenosis. Vascular lesions are the underlying lesions in many diseases, especially in the elderly and metabolic-related diseases, and now some hereditary vascular diseases are also highlighted. Vascular lesions are usually insidious in terms of symptoms, and once they develop the disease progresses rapidly, often with serious complications. Therefore, screening for vascular structure and function must be taken seriously.