Leg cramps in 50s consider calcium deficiency, poor blood circulation in lower limbs, lumbar disc herniation, and give general treatment, physiotherapy, medication, surgery. 1. Calcium deficiency causes leg cramps, it is recommended to take appropriate sun exposure, oral calcium (calcium carbonate capsules) or milk, and apply anti-osteoporosis drugs, such as alendronate, zoledronic acid, etc. For menopausal women, the decrease of estrogen leads to the loss of calcium. For menopausal women with calcium loss due to decreased estrogen, estrogen receptor modulators, such as raloxifene, can also be given appropriately. 2. For leg cramps caused by poor blood circulation in the lower limbs, it is recommended to pay attention to keeping the lower limbs warm, giving massage to the lower limbs, physiotherapy (baking electricity), appropriate activities, such as walking, playing tai chi and so on, the activity time should not be too long, usually about 20 minutes. 3. Lumbar intervertebral disc herniation due to degenerative changes or trauma, causing cramps in the lower limbs, it is recommended to take bed rest in the early stage, give local massage, physiotherapy (infrared rays, short-wave), and apply pain-relieving drugs such as celecoxib, flurbiprofen-ester cream, swelling-reducing drugs such as diosmin tablets and nutritive nerve drugs such as methylcobalamin. If the lower limb cramps are not relieved and the pain continues to worsen, surgical treatment is recommended. Leg cramps in over 50 years old is recommended to actively seek medical advice, under the guidance of a physician, medications need to follow the doctor’s instructions reasonable application.