Pancreatic disease, gallbladder disease, renal failure, and acute appendicitis may cause amylase to rise. Amylase is mainly secreted by the pancreas and drained into the digestive tract. When the secretion function of the pancreas is affected or the discharge channel of the pancreas is obstructed after secretion, amylase will be elevated, and pancreatic diseases that cause amylase elevation include pancreatitis, pancreatic cyst, and pancreatic duct blockage. Pancreatic fluid needs to pass through the common bile duct when it is discharged into the duodenum, and gallbladder diseases can affect the bile duct to a certain extent, and patients with gallbladder diseases, such as cholecystitis and gallstones, may also have elevated amylase. When there are kidney diseases, such as renal insufficiency and renal failure, the metabolism of pancreatic fluid will be affected, and these people will also have elevated amylase. In the case of acute appendicitis, the metabolism of amylase is also affected, thus leading to amylase elevation.