Urethral pain with burning sensation when urinating is a relatively common clinical symptom, usually seen in the following 2 cases: 1, acute urinary tract infection, mostly manifested as frequent urination, urinary urgency, urinary pain, according to its cause can be divided into common bacterial infection and special bacterial infection, common bacterial infection is most common is Escherichia coli infection, but the treatment needs to be taken by mouth anti-inflammatory drugs such as levofloxacin class, the course of treatment generally need 3 days; Special bacterial infections, the most common is gonococcal infection, belong to sexually transmitted diseases, in addition to the above symptoms, there are more typical urethral urethral urethral redness and swelling, urethral secretion of yellowish-white purulent liquid, the treatment of first choice ceftriaxone medication, the course of treatment generally need 1 week, avoid sex during the treatment period of more than 1 month. 2, acute prostatitis, generally manifested as urinary frequency, urinary urgency, urinary pain, anal discomfort, frequent bowel movements, and even accompanied by fever. Even with fever, treatment requires intravenous application of anti-inflammatory drugs, preferred levofloxacin.