The fact that there is no antibody after three times of hepatitis B vaccination does not mean that the body is not susceptible to infection, and the body is more susceptible to hepatitis B virus without hepatitis B protective antibody. The absence of antibody after hepatitis B vaccination, that is, the absence of immune response, is influenced by a variety of factors, mainly vaccine factors, the body’s own characteristics and environmental characteristics, immune-related genetic factors and molecular characteristics, among which immune-related genetic factors and molecular characteristics play a key role in the immune response to hepatitis B vaccine. The body limits the intensity, scope, degree and duration of the immune response generated by antigenic stimulation through the positive and negative regulatory mechanisms of the complex immune network system, but there is no study in domestic and international literature that shows that hepatitis B vaccine non-responders are not susceptible to hepatitis B virus infection. Hepatitis B surface antibody is a protective antibody, and the risk of hepatitis B infection is increased when the body is not protected by protective antibody. For those who have not produced antibodies after repeated vaccination with hepatitis B vaccine, it is recommended to consult a medical professional.