To determine whether hypogonadotropic hypogonadism requires GNRH pulse pump (pituitary pump) treatment, look at the following three simple criteria: 1) Diagnosis of hypogonadotropic hypogonadism is confirmed; 2) Laboratory tests show low LH, FSH, testosterone, or estradiol, but other normal; 3) Gonarelin excitation test results, the pituitary gland shows sensitivity to Gonarelin; or wear GNRH pulse pump (pituitary pump) for one month, there are significant changes in LH, FSH, testosterone, or estradiol. There is a significant change in LH, FSH, testosterone, or estradiol; meeting the above three criteria can choose to wear GNRH pulse pump (pituitary pump) to treat hypogonadotropic hypogonadism. GNRH pulse pump therapy 1, GnRH pulse therapy using the GnRH drug: Gonarelin, intravenous injection of 2 minutes, the blood concentration is peak, the half-life of 20 minutes, very suitable for simulating GnRH pulse. Other types of long-acting GnRH analogues are usually used to interfere with normal GnRH secretion in the hypothalamus, so they are not recommended for pulse therapy use. 2.Initial setup of GnRH pulse therapy (1) Gonarelin solution configuration and installation: Gonarelin for injection, pumped into reservoir at a concentration of 200 μg/ml and placed in the GnRH pulse pump, connected to the infusion tube and subcutaneous infusion device. (2) Initial dose and frequency setting Set the pulse pump for 1 pulse every 90 minutes, 10μg subcutaneous infusion each time, for a total of 16 pulses in 24 hours.