Female breast superficial hard subcutaneous nodules such as elephant skin is infected with filarial mosquito bites the human skin and cause disease. After infected mosquitoes bite the human skin, microfilariae enter the lymphatic vessels, and microfilariae and adult worms enter the breast lymphatic vessels, causing filarial lymphangitis, followed by lymphangitis, forming eosinophilic granuloma and a series of pathological changes. The prevention methods of subcutaneous nodules of female breast superficial hard texture like elephant skin: 1, pay attention to personal hygiene or public health, avoid direct or indirect contact with the secretions, excretions and other items of patients who have developed the disease without timely cleaning and disinfection leading to the infection of the disease. 2, mosquito prevention and control. Strengthen the epidemiological surveillance of areas that have reached the basic elimination of filariasis indicators. Found infected mosquitoes, that is, infected mosquito households as the center, to the surrounding population to expand the blood check and mosquito control, in order to clear the epidemic site to prevent the continued spread. 3, early detection of patients and insect carriers, timely cure, both to ensure the health of the people, but also to reduce and eliminate the source of infection. 4, to protect the susceptible population, in the endemic areas using the sea group life salt therapy, each kilogram of salt mixed with sea group life 3g, an average of 16.7g of salt per person per day, containing sea group life 50mg, even for six months, can reduce the rate of microfilaria positive in the population. 5, bacterial infections, rivers, lakes and seas, humid climate, forests, more stifling heat, germs breed and multiply quickly, a variety of fungal infections are prone to increase. Such as Cryptococcus, often parasitic in the soil or feces, can enter the body through the mouth, causing infection. Because the clinical symptoms of fungal infections are not typical, it is easy to misdiagnose. Therefore, it is important to strengthen personal hygiene and health care, and improve their own immunity.