The burning pain in the urethra during sleep may be caused by urethral stones, urethritis, prostatitis and other factors. 1. Urethral calculi: can be secondary to bladder stones, in the night sleep turn over, the stone may move, the urethra local irritation, can lead to urethral burning pain wake up, may also be accompanied by frequent urination, urinary urgency, urination difficulties, hematuria and other symptoms. 2. Urethritis: it may be related to not paying attention to physical hygiene or unclean sex, due to the presence of infection in the urethra, causing damage to the urethral mucosa, can lead to burning sensation of the urethra when sleeping, may also be accompanied by urethral itching, urinary urgency, urinary frequency, urethral secretion increase and other symptoms. 3. Prostatitis: due to the presence of prostate infection, resulting in localized enlargement of the prostate gland as well as damage to the urethra burning sensation, waking up with pain, may also be accompanied by frequent urination, urinary urgency, urinary incontinence and other symptoms. There are many reasons for waking up with burning pain in the urethra while sleeping, and it is recommended to consult a doctor for appropriate examination and treatment.