Progesterone is mainly used clinically for urinary stones and is usually given in 2 shots. Stones in other areas, such as gallbladder stones and common bile duct stones, are usually not treated clinically with progesterone. Urinary stones, especially ureteral stones, can lead to ureteral smooth muscle spasm causing renal colic, nausea, vomiting, severe pain in the lower back and abdomen, blood in the urine, urinary frequency and other symptoms. By intramuscular injection of progesterone injection 20 mg once in the morning and once in the evening, the spasm of smooth muscle can be relieved, the symptoms of renal colic can be relieved, and the discharge of stones from the body can be promoted. The use of the drug should be noted that it may cause adverse reactions such as nausea, dizziness and headache, feeling of tiredness. The drug is contraindicated in patients with severe liver damage. Progesterone can only relieve the symptoms caused by stones, if the stones are relatively large and difficult to expel by themselves, you can use extracorporeal shock wave lithotripsy or surgical lithotripsy.