Squamous carcinoma refers to squamous cell carcinoma, a type of pathology, and hypo-differentiated refers to a low degree of differentiation. Squamous carcinomas are undifferentiated, poorly differentiated, moderately differentiated, and highly differentiated based on the degree of differentiation; the lower the degree of differentiation, the more malignant the tumor. Hypo-differentiated squamous cell carcinoma occurs in the skin, oral cavity, cervix and bronchi. Hypofractionated squamous carcinoma usually presents with a cauliflower-like appearance, and in severe cases, the tumor tissue may be shed and ulcers may develop at the site of shedding. For example, in early stage, hypofractionated squamous carcinoma shows red hard nodules on the skin surface, which will turn into some warts as the disease progresses, and then ulcers and purulent discharge will appear, and most of the ulcers will produce a foul smell. After diagnosed with hypofractionated squamous carcinoma, patients should carry out targeted treatment under professional doctor’s guidance in time.